Feb 18, 2025 · Detecting toxic forms of tau before they weave into dense thickets of tangles could pave the way for earlier diagnosis and treatment of tauopathies, including Alzheimer’s disease. …

Feb 5, 2024 · Recognizes tau doubly phosphorylated at serines 396 and 404 Immunoreactivity seen in Alzheimer's disease and other tauopathies but not controls Used to assess the …

May 22, 2020 · Many research groups study tau misfolding and propagation using in vitro models, but interpreting findings from artificial systems can be dicey. In a preprint on bioRxiv, …

In both wild-type C57BL/6 and P301L mutant tau transgenic mice, a three-month regimen of subcutaneous ACI-35 injection rapidly generated high titers of polyclonal IgG antibodies …

Jan 30, 2025 · Tau, Incorporated. A library of tau mutants generated by alanine substitution (red residues, left), was transduced into biosensor cell lines containing pre-existing tau fibril strains. …

Feb 6, 2024 · Hyperphosphorylated tau polymerizes into paired helical filaments, which aggregate to form neurofibrillary tangles, one of the defining lesions of Alzheimer’s disease. Recognizes …

May 1, 2025 · They accumulated hyperphosphorylated tau in their brains and lost synapses by approximately 15 months of age, but they had no tau oligomers capable of seeding …

Tau pathology is widely considered to be downstream of Aβ pathology and is more closely linked to cognitive deficits in Alzheimer's disease. Mutations in the tau gene cause frontotemporal …

Feb 6, 2024 · The interaction of MC-1 with recombinant tau suggests that post-translational modifications are not required to generate the MC-1 epitope. However, it remains possible that …

Aug 14, 2014 · This widely used tauopathy model was developed at the University of Pennsylvania School of Medicine by Virginia Lee, John Trojanowski, and colleagues. As first …