The 49ers are even more depleted at wide receiver in Week 3, placing greater emphasis on their star running back.

The Arizona Cardinals will face the San Francisco 49ers Sunday in Week 3. They kick off at 4:25 p.m. ET (1:25 p.m. Arizona ...

McCaffrey is back at it after a lost 2024 season and another injury scare. "He looks like OPOY Christian," Trent Williams ...

San Francisco 49ers running back Christian McCaffrey caught a touchdown in the second quarter of Sunday's game against the ...

Here are five takeaways from the 49ers' tough win against the Cardinals. Nick Bosa exited the game in the first quarter with ...

San Francisco 49ers QB Mac Jones delivered a 20-yard strike to RB Christian McCaffrey in the team's Week 3 matchup against ...

NEW ORLEANS, LOUISIANA – SEPTEMBER 14: Mac Jones #10 of the San Francisco 49ers is congratulated by Christian McCaffrey #23 ...

The first play in the final quarter brought some controversy, as the 49ers believed they got a safety on Murray, who threw the ball away for intentional grounding near the goal line - though replay ...

Christian McCaffrey Mac Jones National Football League NFL - Arizona Cardinals vs. San Francisco 49ers - 09/21/2025 San Francisco 49ers ...

Recently signed kicker Eddy Pineiro made a 35-yard field goal on the final play to give the San Francisco 49ers a 16-15 win ...

Eddy Pineiro drilled a 35-yard field goal as time expired to lift the San Francisco 49ers to a 16-15 win over the Arizona Cardinals on Sunday afternoon in Santa Clara, Calif.

Christian McCaffrey is averaging just 3.5 yards per carry this season -- a career low. And his longest run of the season has gained just 13 yards.