The 49ers are even more depleted at wide receiver in Week 3, placing greater emphasis on their star running back.

The Arizona Cardinals will face the San Francisco 49ers Sunday in Week 3. They kick off at 4:25 p.m. ET (1:25 p.m. Arizona ...

Here are five takeaways from the 49ers' tough win against the Cardinals. Nick Bosa exited the game in the first quarter with ...

The first play in the final quarter brought some controversy, as the 49ers believed they got a safety on Murray, who threw the ball away for intentional grounding near the goal line - though replay ...

Christian McCaffrey Mac Jones National Football League NFL - Arizona Cardinals vs. San Francisco 49ers - 09/21/2025 San Francisco 49ers ...

Recently signed kicker Eddy Pineiro made a 35-yard field goal on the final play to give the San Francisco 49ers a 16-15 win ...

Eddy Pineiro drilled a 35-yard field goal as time expired to lift the San Francisco 49ers to a 16-15 win over the Arizona Cardinals on Sunday afternoon in Santa Clara, Calif.

San Francisco 49ers QB Mac Jones threads a 34-yard pass to WR Ricky Pearsall along the sideline against the Arizona Cardinals in Week 3 of the 2025 season.

San Francisco 49ers WR Ricky Pearsall hauls in a 20-yard reception against the Arizona Cardinals in Week 3 of the 2025 season.

Catch up on all the NFL action from week three as the Philadelphia Eagles and San Francisco 49ers claim late wins, while the ...

Arizona Cardinals inside linebacker Mack Wilson Sr. breaks up the pass intended for San Francisco 49ers running back Christian McCaffrey during Week 3 of the 2025 NFL season.

The Arizona Cardinals and San Francisco 49ers meet in Week 3 of the NFL season Sunday afternoon at Levi's Stadium.