San Francisco is a 2.5-point favorite in the latest Cardinals vs. 49ers odds from SportsLine consensus, while the over/under ...

Game prediction: Cardinals 23, 49ers 22. The Niners’ defense performs again, allowing only two touchdowns, but the San ...

Barring a significant last-minute change, the San Francisco 49ers will start Mac Jones at quarterback for a second ...

Mac Jones is in line to make a second straight start under center for the San Francisco 49ers after the team listed ...

The Inside the Lines team uses its proven NFL model to break down why our projected rankings for Week 3 differ significantly ...

49ers starting quarterback Brock Purdy, who has been dealing with a toe injury, is “highly unlikely to start” against the ...

Expect Mac Jones to be behind center for the 49ers Sunday, and 49ers will look to break loose with running game.

San Francisco quarterback Mac Jones humorously recalled the moment when current 49ers teammate Bryce Huff sacked him.

Jones affirmed the 49ers' faith, delivering in a pass-heavy game plan and showing why the team won't rush Purdy back into ...

Mac Jones misfired on his first four passes and then validated the 49ers’ decision to sign him in free agency.

For the second season in a row, the San Francisco 49ers are being hit hard by key injuries. Wide receiver Brandon Aiyuk is ...

Because there he was, Mac Jones, leading the 49ers’ offense to a gritty 26-21 win over the Saints. Now we all know that after ...