Our NFL expert offers his Cardinals vs 49ers predictions, picks, and odds for their NFL Week 4 battle at 4:25pm EDT (9/21).

San Francisco is a 2.5-point favorite in the latest Cardinals vs. 49ers odds from SportsLine consensus, while the over/under ...

Arizona Cardinals fantasy football Week 3 guide vs. 49ers. Updated DraftKings & FanDuel salaries, start/sit picks, ...

The San Francisco 49ers face the Arizona Cardinals on Sunday, Sept. 21, 2025 in Week 3 of the NFL season at State Farm ...

Arizona’s 24-23 win on Oct. 6 of last season, a game in which the 49ers led 23-10, helped chart the path to a 6-11 season.

Arizona comes into this game 2-0, but as a more flawed team than the one that swept San Francisco last year. The Cardinals' running game has not gotten untracke ...

A chance at becoming 3-0 is within reach for the San Francisco 49ers. All they have to do is duke it out with the Arizona Cardinals to get there. However, that' ...

The Niners are without their starting quarterback, Brock Purdy, and have Mac Jones at the helm. He struggled with turning the ball over between his time with the New England Patriots and Jacksonville ...

Last week, Cardinals QB Kyler Murray apologized — too late — after posting a photo with his pet pit bull while Murray wore a ...

The Cardinals are sixth in rushing yards allowed per game (78), 10th in yards per attempt allowed (3.8), and ninth in passer ...

Jackson Arnold was expected to be the next big thing at Oklahoma, another great quarterback at a school that produced Heisman ...