The San Francisco 49ers (2-0) host an NFC West showdown against the Arizona Cardinals (2-0) on Sunday, September 21, 2025 at ...

The San Francisco 49ers face the Arizona Cardinals on Sunday, Sept. 21, 2025 in Week 3 of the NFL season at State Farm ...

The Sunday afternoon Cardinals vs. 49ers game will kick off at 4:25 p.m. ET on FOX. (Out-of-market fans can catch the game on ...

Happy gameday one and all. The Arizona Cardinals are taking on their division rival San Francisco 49ers this afternoon and it ...

Learn which TV channel or how to live stream the NFL Week 3 San Francisco 49ers and Arizona Cardinals game, Sunday, Sept. 21.

Arizona comes into this game 2-0, but as a more flawed team than the one that swept San Francisco last year. The Cardinals' ...

Mac Jones is expected to again start in place of Brock Purdy as the 49ers host the Arizona Cardinals on Sunday.

San Francisco is a 2.5-point favorite in the latest Cardinals vs. 49ers odds from SportsLine consensus, while the over/under ...

Starting Monday, Gilman Playground, Laurelhurst Playfield, and Mount Baker Park will be open from 7 a.m. to 10 p.m. on ...

The Arizona Cardinals made their two standard practice squad elevations ahead of Week 3's road test against the San Francisco ...

Preview the San Francisco 49ers' NFL week 3 matchup with the Cardinals, including betting odds, tips, trends, and game ...

Game prediction: Cardinals 23, 49ers 22. The Niners’ defense performs again, allowing only two touchdowns, but the San ...