Mac Jones is expected to again start in place of Brock Purdy as the 49ers host the Arizona Cardinals on Sunday.

Arizona Cardinals QB Kyler Murray is always a handful for defensive coordinators thanks to his natural arm talent and elite athleticism to extend plays and gain serious yardage with his legs. The San Francisco 49ers know that best, especially after being swept by the Cardinals in 2024.

The Arizona Cardinals have a chance at a 3-0 start when they head to San Francisco to take on the 49ers. It's their toughest matchup yet this year.

Murray shined last season against the 49ers, starting on his second snap when he raced 50 yards for a touchdown and not slowing down. Murray capped that game at Levi’s Stadium by throwing a TD pass in the fourth quarter and leading a game-winning field-goal drive as the Cardinals erased a 10-point deficit.

www.si.com/nfl/49ers Why these injuries could swing the 49ers' Week 2 matchup vs. Arizona East Grays Harbor Fire and Rescue says it had put out a car fire that was close to a building in the Murray Place neighborhood. Fire crews arrived on the scene of the fire at about 8:20 p.m.

The Arizona Cardinals dominated on the ground in 2024, finishing second in yards per carry. 2025 has been more of a struggle for their rushing attack.

USA Today's NFL experts make their picks for a Week 3 showdown between the San Francisco 49ers and Arizona Cardinals

The Arizona Cardinals and San Francisco 49ers both hope to emerge to 3-0 to begin the 2025 season, though the NFC West rivals stand in each other's way of doing just that on Sunday. Arizona is 2-0 for the first time since 2021 while the Niners have now done so in the last three-of-five seasons.

Wolf & Luke have former NFL linebacker Lorenzo Alexander break down the Cardinals’ blueprint to slow Christian McCaffrey and Kyle Shanahan’s offense if George Kittle is out and Brock Purdy is in doubt: swarm tackles,