The 49ers are even more depleted at wide receiver in Week 3, placing greater emphasis on their star running back.

The Arizona Cardinals will face the San Francisco 49ers Sunday in Week 3. They kick off at 4:25 p.m. ET (1:25 p.m. Arizona ...

The Arizona Cardinals and San Francisco 49ers meet in Week 3 of the NFL season Sunday afternoon at Levi's Stadium.

The San Francisco 49ers are 2-0 and are favored to get to 3-0 against a division rival. Overall, things are good. However, if there is a problem, it is quite apparent to fans, media, and anyone who ...

San Francisco 49ers stars George Kittle and Fred Warner join Christian McCaffrey on the Saudi Arabia flag football team.

The San Francisco 49ers are looking to rebound after an uneven 2024 season that saw the team finish 6-11 amidst a litany of injuries to key skill positions.

Next up for the Arizona Cardinals are the San Francisco 49ers. Both teams are 2-0 to start the season, although both teams have questions. The Niners have been devastated by injuries. Quarterback ...

Reports indicate that Juszczyk, who is 34 years old, cleared concussion protocol, according to Matt Barrows of The Athletic. Running back Christian McCaffrey and the 49ers can expect their star ...

Christian McCaffrey is averaging just 3.5 yards per carry this season -- a career low. And his longest run of the season has gained just 13 yards.

The Arizona Cardinals play the San Francisco 49ers Sunday afternoon in Week 3 for their first division game of the year, and after missing him in both games last season, they will have to deal with ...

McCaffrey is back at it after a lost 2024 season and another injury scare. "He looks like OPOY Christian," Trent Williams ...

The death of political activist Charlie Kirk has sent shockwaves around the country, including the sports world. Even San Francisco 49ers star tight end George Kittle was thrown ...