The 49ers are even more depleted at wide receiver in Week 3, placing greater emphasis on their star running back.

The Arizona Cardinals will face the San Francisco 49ers Sunday in Week 3. They kick off at 4:25 p.m. ET (1:25 p.m. Arizona ...

McCaffrey is back at it after a lost 2024 season and another injury scare. "He looks like OPOY Christian," Trent Williams ...

San Francisco 49ers running back Christian McCaffrey caught a touchdown in the second quarter of Sunday's game against the ...

Christian McCaffrey is averaging just 3.5 yards per carry this season -- a career low. And his longest run of the season has gained just 13 yards.

The Arizona Cardinals and San Francisco 49ers meet in Week 3 of the NFL season Sunday afternoon at Levi's Stadium.

The Arizona Cardinals play the San Francisco 49ers Sunday afternoon in Week 3 for their first division game of the year, and after missing him in both games last season, they will have to deal with ...

American football will now be played in Saudi Arabia, in the latest move by the Kingdom to corner the country's sports market ...

San Francisco 49ers star Christian McCaffrey missed practice Friday and was being listed as questionable for the team's Week ...

Get the latest 49ers vs. Saints Week 2 betting preview with injury updates, data-driven predictions, projected box score ...

The San Francisco 49ers are starting the 2025 season with several doubts on offense, and one of the most talked about is Christian McCaffrey's calf injury. However, although the ne ...

Christian McCaffrey popped up on the injury report on Thursday and didn't practice Friday. Will he play Sunday?