The 49ers are even more depleted at wide receiver in Week 3, placing greater emphasis on their star running back.

The Arizona Cardinals will face the San Francisco 49ers Sunday in Week 3. They kick off at 4:25 p.m. ET (1:25 p.m. Arizona ...

McCaffrey is back at it after a lost 2024 season and another injury scare. "He looks like OPOY Christian," Trent Williams ...

The 49ers just beat the New Orleans Saints 26-21 and improved their record to 2-0. Here are the 49ers' grades for this ...

San Francisco 49ers running back Christian McCaffrey caught a touchdown in the second quarter of Sunday's game against the ...

NEW ORLEANS, LOUISIANA – SEPTEMBER 14: Mac Jones #10 of the San Francisco 49ers is congratulated by Christian McCaffrey #23 ...

Christian McCaffrey is averaging just 3.5 yards per carry this season -- a career low. And his longest run of the season has gained just 13 yards.

The Arizona Cardinals and San Francisco 49ers meet in Week 3 of the NFL season Sunday afternoon at Levi's Stadium.

The Arizona Cardinals play the San Francisco 49ers Sunday afternoon in Week 3 for their first division game of the year, and after missing him in both games last season, they will have to deal with ...

American football will now be played in Saudi Arabia, in the latest move by the Kingdom to corner the country's sports market ...

San Francisco 49ers stars George Kittle and Fred Warner join Christian McCaffrey on the Saudi Arabia flag football team.

San Francisco 49ers QB Mac Jones, LB Fred Warner, RB Christian McCaffrey, DL Nick Bosa, and WR Jauan Jennings reflected on ...