The San Francisco 49ers face the Arizona Cardinals on Sunday, Sept. 21, 2025 in Week 3 of the NFL season at State Farm Stadium in Glendale, Arizona.

The San Francisco 49ers and Arizona Cardinals will meet on Sunday. Here's what fantasy owners should do with their 49ers in Week 3.

Moody said the transition has been "smooth.'' He already has benefitted from working with kicker Cairo Santos and special-teams coordinator Richard Hightower.

Martinez spent four seasons as the starting quarterback for the Nebraska Cornhuskers before transferring to Kansas State for his final collegiate season in 2022. He signed with the Detroit Lions as an undrafted free agent in 2023, but was waived before the start of his rookie season.

Play the USA TODAY Quick Cross now. With Moody a popular target for the fans' frustrations, 49ers fans were quick to voice their displeasure with the 2023 third-round NFL draft pick on Sunday. Moody followed up by having his 36-yard field goal try blocked ...

San Francisco defensive back Ji'Ayir Brown claims he's a 'top five' safety in NFL despite demotion in third season with 49ers.

The San Francisco 49ers defeated the New Orleans Saints in Week 2. How did it affect how Kyle Shanahan's team is being viewed in Week 3.

The standard elevation of QB Adrian Martinez from the practice squad means Brock Purdy can no longer serve as an emergency third quarterback; he may still suit up against the Cardinals.