San Francisco is a 2.5-point favorite in the latest Cardinals vs. 49ers odds from SportsLine consensus, while the over/under ...

Game prediction: Cardinals 23, 49ers 22. The Niners’ defense performs again, allowing only two touchdowns, but the San ...

Expect Mac Jones to be behind center for the 49ers Sunday, and 49ers will look to break loose with running game.

San Francisco coach Kyle Shanahan said it’s “ highly unlikely ” Brock Purdy would return as the 49ers’ starting quarterback on Sunday, which means it’s highly likely Mac Jones will be under center for ...

Coach Kyle Shanahan said Friday that if 49ers wanted Purdy to be suited up as the emergency No. 3 quarterback, then Martinez, ...

After drawing his first start of the season last week, former Alabama Crimson Tide quarterback Mac Jones is set to start for ...

The 49ers elevated quarterback Adrian Martinez from the practice squad for Sunday's game against the Cardinals, the team ...

Calais Campbell isn't afraid to say that the Arizona Cardinals are looking forward to the opportunity to play against Mac Jones ...

The 49ers host the Cardinals in Week 3 on Sunday, September 21, 2025. With Brock Purdy unlikely to play, Mac Jones gets the start as San Francisco enters as a slight favorite. See odds, predictions, ...

Mac Jones is expected to again start in place of Brock Purdy as the 49ers host the Arizona Cardinals on Sunday.

Having said that, Mariota did come in in relief for Daniels on three occasions last season, throwing for 364 yards and four touchdowns while also adding a score on the ground. The Commanders could ...

Arizona comes into this game 2-0, but as a more flawed team than the one that swept San Francisco last year. The Cardinals' ...