If the Cardinals are forced to be one-dimensional, the Niners’ defensive line has the advantage. Arizona is down Paris ...

San Francisco is a 2.5-point favorite in the latest Cardinals vs. 49ers odds from SportsLine consensus, while the over/under ...

Arizona Cardinals fantasy football Week 3 guide vs. 49ers. Updated DraftKings & FanDuel salaries, start/sit picks, ...

The San Francisco 49ers face the Arizona Cardinals on Sunday, Sept. 21, 2025 in Week 3 of the NFL season at State Farm ...

Arizona’s 24-23 win on Oct. 6 of last season, a game in which the 49ers led 23-10, helped chart the path to a 6-11 season.

Arizona comes into this game 2-0, but as a more flawed team than the one that swept San Francisco last year. The Cardinals' running game has not gotten untracke ...

Last week, Cardinals QB Kyler Murray apologized — too late — after posting a photo with his pet pit bull while Murray wore a ...

Jackson Arnold was expected to be the next big thing at Oklahoma, another great quarterback at a school that produced Heisman ...

Preparing to defend against one of college football's most dynamic quarterbacks had Texas Tech head coach Joey McGuire wishing Utah ran a more pro-style offense ...

The Arizona Cardinals have a chance at a 3-0 start when they head to San Francisco to take on the 49ers. It's their toughest matchup yet this year.

Football is a team sport to be sure, but no player on the field has more of an impact on every play than the quarterback. With some stars emerging in the ...