San Francisco is a 2.5-point favorite in the latest Cardinals vs. 49ers odds from SportsLine consensus, while the over/under ...

Arizona Cardinals fantasy football Week 3 guide vs. 49ers. Updated DraftKings & FanDuel salaries, start/sit picks, ...

The San Francisco 49ers face the Arizona Cardinals on Sunday, Sept. 21, 2025 in Week 3 of the NFL season at State Farm ...

Arizona’s 24-23 win on Oct. 6 of last season, a game in which the 49ers led 23-10, helped chart the path to a 6-11 season.

The Cardinals are sixth in rushing yards allowed per game (78), 10th in yards per attempt allowed (3.8), and ninth in passer ...

Last week, Cardinals QB Kyler Murray apologized — too late — after posting a photo with his pet pit bull while Murray wore a ...

Arizona comes into this game 2-0, but as a more flawed team than the one that swept San Francisco last year. The Cardinals' running game has not gotten untracke ...

Arizona Cardinals QB Kyler Murray is always a handful for defensive coordinators thanks to his natural arm talent and elite athleticism to extend plays and gain serious yardage with his legs. The San ...

The Niners are without their starting quarterback, Brock Purdy, and have Mac Jones at the helm. He struggled with turning the ball over between his time with the New England Patriots and Jacksonville ...

Here is everything you need to know about the San Francisco 49ers vs. Arizona Cardinals, including TV and streaming options for the Week 2 NFL game.