A 31-year-old man was evaluated for an abnormal ECG. Echocardiography revealed marked ventricular hypertrophy. Subsequent ...

Personalized therapies hold tremendous promise but challenge traditional models of drug and biologic development. The FDA outlines a path to market entry for products where a randomized trial is no ...

Once-daily, single-tablet regimens have transformed care for persons living with human immunodeficiency virus type 1 (HIV-1); ...

As legislative support for medical aid in dying grows, the paradox at the heart of this option, with its broader-than-expected benefits, becomes increasingly clear: its expansion hinges on its rarity.

How can we change a system, and a culture, in which suicide can look to physicians like an attractive escape from the relentless demands of medical practice?

Big data, we have all heard, promise to transform health care. But in the “hype cycle” of emerging technologies, machine learning now rides atop the “peak of inflated expectations,” and we need to ...

A 29-year-old man presented with an acute onset of right pleuritic chest pain and a 3-month history of dyspnea, cough, and skin lesions. Physical examination revealed crackles in both lungs and ...

When a patient receives a diagnosis of amyotrophic lateral sclerosis, he is shocked. But he’s also dubious enough to seek a second opinion.

Health worker burnout, exacerbated by Covid-19, is not only about long hours. It’s about the fundamental disconnect between health workers and the mission to serve that motivates them.

A 45-year-old man presented with a 2-month history of worsening pain and swelling in his right shoulder. A radiograph showed destruction of the humeral head with a free-floating humeral diaphysis.

In 832 patients with rare genetic disease, a conclusive diagnosis was made for 160 patients (19.2%) with long-read genome sequencing and for 137 patients (16.5%) with standard-of-care testing.

Explore this issue of The New England Journal of Medicine (Vol. 395 No. 4).