News

eLife21h
The microbiome interacts with the circadian clock and dietary composition to regulate metabolite cycling in the Drosophila gut
The Drosophila microbiome regulates the cycling of gut metabolites in a circadian clock and diet-dependent manner.
eLife4d
Magnetically steered cell therapy for reduction of intraocular pressure as a treatment strategy for open-angle glaucoma
Magnetically steered mesenchymal stem cells significantly lowered intraocular pressure for 9 months in mice, motivating the translation of this technology for the treatment of glaucoma.
eLife3d
REPOP: bacterial population quantification from plate counts
This important study introduces a Bayesian method to determine bacterial counts that accounts for the experimental noise inherent to dilution and plating methods, and distinguishes it from biological ...
eLife3d
Longitudinal tracking of neuronal activity from the same cells in the developing brain using Track2p
This important study presents a new method for longitudinally tracking cells in two-photon imaging data that addresses the specific challenges of imaging neurons in the developing cortex. It provides ...
eLife10d
Current insights into insect immune memory
Insects possess a remarkable ability to develop innate immune memory, and the mechanisms underlying this process are becoming a central topic in innate immunity research.
eLife4d
Reorganization of spinal neural connectivity following recovery after thoracic spinal cord injury: insights from computational modelling
Rats exhibit significant recovery of locomotor function following incomplete spinal cord injuries, albeit with altered gait expression and reduced speed and stepping frequency. These changes likely ...
eLife7d
Cestode larvae excite host neuronal circuits via glutamatergic signalling
Parasitic tapeworm larvae release glutamate and other excitatory molecules that can directly excite brain neurons.
eLife11d
Methylation: Modifying gene expression through passive forces
The mRNA metabolism passively shapes the levels of an mRNA modification called m6A within a steady-state cell and upon stress.
eLife9d
RNA: Searching for druggable targets
A strategy that analyzes the structural properties of RNA could help identify regions that are promising targets for antiviral drugs.
eLife8d
Assemblies, synapse clustering, and network topology interact with plasticity to explain structure-function relationships of the cortical connectome
This useful study presents a biologically realistic, large-scale cortical model of the rat's non-barrel somatosensory cortex, investigating synaptic plasticity of excitatory connections under varying ...
eLife3d
Quantitative intra-Golgi transport and organization data suggest the stable compartment nature of the Golgi
Quantitative measurements of intra-Golgi transport kinetics of diverse secretory cargos challenge the classic cisternal progression model and support the stable compartment model of the Golgi.
eLife3d
Epithelial cell chirality emerges through the dynamic concentric pattern of actomyosin cytoskeleton
The chirality of tissues and organs is essential for their proper function and development. Tissue-level chirality derives from the chirality of individual cells that comprise the tissue, and cellular ...