Seattle Seahawks coach Mike Macdonald faced an unusual conundrum this week as he game-planned for Sunday's rematch with the San Francisco 49ers. How much stock should he put into the film of the two teams' first meeting given how much both rosters have changed since Seattle's Thursday night loss at Lumen Field last month?

Left tackle Trent Williams’ ankle and wrist injuries could force him to miss his first 49ers game this season Sunday against the Seahawks.

Seattle Seahawks starting Connor Williams missed Wednesday’s and Thursday’s practice. His designation on the injury report is “personal reasons.” Members of the media are unaware of the reason behind his absence. Williams is entitled to a personal life and doesn’t owe us details.