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Seahawks vs. 49ers prediction: Odds, expert picks, QB matchup, injury update, betting trends, and stats

The NFC West and the top overall seed in the conference is on the line Saturday at Levi’s Stadium when the San Francisco 49ers (12-4) host the Seattle Seahawks (13-3).

· 19h

Seahawks vs. 49ers Prediction, Odds, Spread, Injuries, Trends for NFL Week 18

· 4h · on MSN

NFL Week 18 picks and score predictions: 49ers win thriller over Seahawks, Ravens-Steelers goes down to wire

· 1d

What people are saying about Seahawks-49ers showdown (and timing)

After disposing of the Panthers on Sunday, the Seahawks tied a franchise record with 13 wins this season.

Cards Wire · 1d

NFC West title, No. 1 seed in NFC comes down to 1 Week 18 game

· 1d

What we learned in NFL Week 17: 49ers, Seahawks set up clash for NFC’s top seed

· 1d

Here’s when Seahawks will play 49ers in Week 18

The game will kickoff at 5 p.m. PT and be broadcast on ESPN/ABC.

· 1d

Brock Purdy outduels Caleb Williams with 5 total TDs, boosts 49ers' top seed hopes on 'Sunday Night Football'

· 1d

49ers outlast Bears in thrilling shootout: Live updates and reaction from NFL “Sunday Night Football”

49ers, Seahawks and NFC

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· 2h · on MSN

Fans excited as 49ers, Seahawks battle for NFC's top seed

Gomez was shopping at Levi's Stadium's team store on Monday evening. As a lifelong Niners fan, he wanted to get his family in the spirit ahead of Saturday's high-stakes game against the Seattle Seahawks.

· 23h · on MSN

49ers win sets up clash with Seahawks for NFC West top playoff seed

· 1d

Seahawks beat Panthers 27-10 for 6th straight win, still need to beat 49ers for No. 1 seed

Winnipeg Free Press · 1d

Buccaneers are still in the race for the NFC South title despite an eighth loss in 10 games

The Tampa Bay Buccaneers have collapsed in the second half but still remain alive in the playoff race despite a 20-17 loss at Miami on Sunday.

· 1d

NFC West-best Seahawks stifle Panthers, win 6th straight

· 1h

Panthers’ locker room picks 2025 MVPs on offense, defense and special teams

· 18h

How many NFL teams have made playoffs with a losing record? Bucs can join small list

The 7-9 Buccaneers will battle the 8-8 Carolina Panthers with a chance to claim the NFC South title in Week 18 at Raymond James Stadium in Tampa, Florida.

· 20h

What went wrong with the Panthers offense in Week 17 loss to Seahawks?

· 1d

Panthers could have wrapped up the NFC South title. Now they likely need a win in Week 18

2hon MSN

Seahawks-49ers week kicks off with trash talk from rival CB

Sunday's division-deciding Week 18 clash between the Seattle Seahawks and San Francisco 49ers kicks off with trash talk from rival CB.

49ers offense sizzles while Seahawks’ Sam Darnold sputters: Week 17 film review

Quarterback Brock Purdy looks healthy again and is playing better than he was when the 49ers went to the Super Bowl. He’s executing the offense and hitting the wide-open receivers created by the scheme, but his playmaking ability is taking this offense to the next level.

13h

49ers-Seahawks set for Saturday night kickoff in regular-season finale

Sunday’s finale will bookend a season that started with the 49ers in Seattle, eking out a 17-13 victory over the Seahawks as a late Brock Purdy touchdown to Jake Tonges earned them their first win of the season. Seattle has won 11 of its last 13 games to set up this showdown that will determine the NFC West.

11h

Rams' loss on MNF opens NFC West door for Seahawks vs. 49ers in Week 18

Rams' loss on MNF opens NFC West door for Seahawks vs. 49ers in Week 18 originally appeared on The Sporting News. Add The Sporting News as a Preferred Source by clicking here. The Los Angeles Rams ' Week 17 loss to the Atlanta Falcons was brutal for the fans.

NBC Sports Bay Area on MSN

49ers' Deommodore Lenoir issues blunt warning to Seahawks ahead of Week 18 game

San Francisco 49ers cornerback Deommodore Lenoir discussed the upcoming matchup against the Seattle Seahawks in Week 18 of the 2025 NFL Season.

5hon MSN

NFL Week 18 playoff predictions for Super Bowl 60, AFC, NFC titles

We've reached the final week of the regular season. Here's an early look at some predictions and picks for the 2026 NFL playoffs.