Week 3 of the 2025 NFL season is set to kickoff Thursday night, which means it's time to take a look at what injuries could play a key role across the third week of the new campaign. The San Francisco 49ers could potentially get quarterback Brock Purdy (left shoulder/toe) back in Week 3 with head coach Kyle Shanahan saying Purdy "has a chance" to play this week.

On top of that, defensive tackle B.J. Hill was limited on Thursday with due to non-injury-related rest, while linebacker Logan Wilson returned to full practice after being limited with ankle injury. Rookie defensive end Shemar Stewart remains out with his own ankle injury.

The 49ers are already facing a litany of injuries after their Week 1 matchup against the Seahawks. Among the injured is quarterback Brock Purdy.

Commanders star quarterback Jayden Daniels has been ruled out for Week 3 with a knee injury. The Packers are dealing with injuries to two key offensive weapons in Josh Jacobs and Tucker Kraft. Jaguars wide receiver Brian Thomas Jr. should be good to go, but a wrist injury has been curtailing his effectiveness.