University scientists have identified a gene responsible for initiating the normal development of tooth roots in mammals. Researchers made this discovery by creating a mouse lacking the gene ...

Teeth function not only because of the hard enamel on the surface, but also because they have roots that anchor them firmly in the jawbone beneath the gums. Eating, speaking, and maintaining the shape ...

Tooth root development relies on precise coordination of cellular signals, yet the underlying mechanisms remain unclear. Researchers have uncovered how two proteins, Gli2 and Gli3, work together to ...

BUFFALO, N.Y. -- University at Buffalo scientists have identified a gene responsible for initiating the normal development of tooth roots in mammals. Researchers made this discovery by creating a ...

Schematic diagram illustrating how Gli2 and Gli3 regulate Acvr2b-mediated TGF-β/SMAD signaling to control proliferation and differentiation of dental mesenchymal progenitor cells during tooth root ...

However, the outer layer of HERS extended without the root, and the mutant molars finally erupted. The periodontal tissues invaded extensively into the dental pulp. These results indicate that there ...

A new study published in Nature Communications identifies two distinct stem cell lineages that control how tooth roots and surrounding bone form, offering a major step toward regenerating natural ...

The interaction between Hertwig's epithelial root sheath (HERS) and surrounding mesenchymal cells is crucial for root dentin formation. HERS influences tooth root development and odontoblast ...

Xu, H., Snider, T. N., Wimer, Helen F., Yamada, S. S., Yang, T., Holmbeck, K., and Foster, B. L. 2016. "Multiple essential MT1-MMP functions in tooth root formation ...

Completely dislodging a tooth from the socket is not generally considered a reversible process. However, this injury is most common in children, whose roots may not be completely developed, meaning ...