Researchers found a hidden signal that makes T cells shut down during cancer fights. Turning off this signal reawakens the cells and helps them attack tumors more effectively.

In their new study, the LJI scientists are the first to show that GPR25 is induced by a signaling molecule called TGF-β.

Memory T cells are a special type of white blood cell that "remember" past infections and vaccines, helping our bodies to ...

The Golgi apparatus modifies, sorts and packages proteins to be sent to their final destinations, whether that's within or outside of the cell. It's a core function, but little studied in the setting ...

Ohio State researchers have discovered that exhausted T cells collapse under the weight of misfolded proteins, activating a destructive stress response called TexPSR. Unlike normal stress systems, ...

Researchers investigating ways to reduce exhaustion in cancer-fighting T-cells found that the Golgi apparatus can be used as a simple marker -- more Golgi means a more robust cell. The Golgi apparatus ...

Different subsets of γδ T cells display differential expression of immune checkpoint receptors (ICRs) and have distinct ...

Tumors trigger T-cell exhaustion through a TSP-1–CD47 signaling pathway. Blocking it can restore immune strength and improve cancer treatment.

An engineered viral protein enhanced the anticancer function of T cells in mice, suggesting a new strategy to improve immunotherapy. Courtney and his team sought to exploit this property of TIP to ...