Researchers uncover how manual acupuncture targets spinal inflammation to relieve rheumatoid arthritis pain. Read more!

Glucose drives STAT3 activation in colorectal cancer cells, leading to tumor growth, forming a target for novel therapeutic strategies.

In the open-label FIBROMET trial, metformin treatment was associated with reductions in bone marrow fibrosis and downregulation of key oncogenic signaling pathways in patients wit ...

In a new study published in Science Signaling, University of Michigan researchers have shown that glucose levels sustain the increased STAT3 activation in colorectal cancer cells. Their findings ...

Schematic diagram of the IL-6/JAK/STAT3 signaling pathway activation in mouse liver macrophages. IRs, inhibitory receptors (IRs); ICIs, immune checkpoint inhibitors; IL-6, interleukin-6; ALT, alanine ...

Cataracts remain one of the most prevalent and debilitating eye conditions, often requiring surgical intervention to restore sight. Yet even after surgery, many patients develop anterior subcapsular ...

Abstract Endotrophin (ETP) is a cleavage fragment of collagen VI α3 (COL6A3) that functions as a potent fibrotic and pro-tumorigenic factor. ETP is a ...

Sepsis is a complex clinical syndrome characterized by dysregulated immune responses, systemic inflammation, and multi-organ dysfunction. It involves intricate interactions among multiple signaling ...