Endosomal trafficking and protein sorting constitute fundamental processes that govern the intracellular localisation and recycling of membrane proteins in eukaryotic cells. Endosomes act as central ...
A conceptual illustration showing how ubiquitin-like 3 (UBL3) modification acts as a molecular “tag” that directs selected ...
F.-U. Hartl, W. Neupert, "Protein sorting to mitochondria: evolutionary conservations of folding and assembly," Science, 247:930-38, 1990. Franz-Ulrich Hartl (University of Munich, Germany): "In this ...
Knowing which lysosomal proteins are enriched in which brain cell types will help better understand contribution to neurological disorders.
Messenger RNA, or mRNA, vaccines entered the public consciousness when they were introduced during the COVID-19 pandemic, and both Pfizer-BioNTech and Moderna used the technology in developing their ...
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Ageing slows brain protein clearance and shifts synaptic waste to microglia
By Vijay Kumar Malesu New mouse data reveal that ageing neurons struggle to clear synaptic proteins, shifting the burden to ...
Most of us rely heavily on shipping services like FedEx or UPS to ensure we receive the correct packages. If that system was disrupted, parcels would end up lost or in the wrong place. Similarly, all ...
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