The number of replication origin sequences in the genome does not change during the lifespan of an organism, but the number of active origins does vary according to the developmental stage. In the ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 119, No. 40 (October 4, 2022), pp. 1-12 (12 pages) Eukaryotic chromosomes are organized into structural and ...

Mitochondrial transcription elongation factor maintains the balance between transcription and replication of mitochondrial DNA offering insights into potential treatments for mitochondrial disease and ...

Bioinformaticians have established that the genes in bacterial genomes are arranged in a meaningful order. They describe that the genes are arranged by function: If they become increasingly important ...

Origin-recognition complex (ORC) plays an unexpectedly broad role in the regulation of human cell gene expression, according to a study in the journal Cell Reports. "This is the first detailed study ...

The DNA molecule is located in the cell nucleus as a densely packed complex of DNA and protein, known as chromatin. Wrapped in sections around a core of special proteins known as histones, the DNA ...