Computer simulations visualize in atomic detail how DNA opens while wrapped around proteins. Researchers from the Hubrecht Institute in Utrecht (The Netherlands) and the Max Planck Institute for ...

Individual cells divide through a process called mitosis, during which the cell's copied DNA is separated between two resulting daughter cells. Despite recent advances in cell biology, the mechanism ...

Barcelona, 10 October 2024 - DNA—the molecule that carries the genetic information of all living organisms—is packaged within cells in a complex manner that allows it to function efficiently.

Tokyo, April 14 - A research group led by Hitoshi Kurumizaka, a professor of structural biology at Waseda University, unveiled the crystal structure of an overlapping dinucleosome, a newly discovered ...

We have measured the effect of the histones in the nucleosome core particle on methylation of purines in nucleosome DNA by dimethyl sulfate. By using 32P terminally labeled nucleosome cores, we have ...

Histones serve as slates to a dizzying array of modifications, but researchers are confident they can decipher the epigenetic puzzle. Roughly two meters of DNA gets packed into every cell nucleus in ...

A group including Jonathan Widom at Northwestern University and Eran Segal of the Weizman Institute used sophisticated computer modeling along with experimental approaches to uncover DNA-encoded rules ...

Histones are among the most abundant proteins in the body. They act as spools that help compact DNA so our enormous genomes will fit in the tight space of the nucleus. Each spool is made of eight ...

Feng Cui, Ph.D. is an Associate Professor in the RIT Thomas H. Gosnell School of Life Sciences. He earned a Ph.D. in Bioinformatics and Computational Biology at Iowa State University and subsequently ...

Chromatin remodeling is an important mechanism of regulating eukaryotic gene expression, which makes tightly condensed DNA accessible to various regulatory factors, such as transcription factors and ...