In a recent paper published in Cell Research, a cryo-EM structure reveals the interface between DNA-PKcs and the Ku70/80:DNA complex, together forming the DNA-dependent protein kinase holoenzyme in ...
This is the first study that shows the 3D structure of a molecular complex found in the bacteria Mycobacterium tuberculosis that repairs DNA damage. According to the biochemical data, this reflects a ...
Three biochemical steps of the non-homologous DNA end-joining (NHEJ) process. This figure outlines the key stages of the NHEJ repair mechanism following DNA double-strand breaks. The process can be ...
A new editorial paper titled "WRNing for the right DNA repair pathway choice" has been published in Aging. Premature aging diseases, also called "progeroid syndrome," display signs and features of ...
Extrachromosomal DNA (ecDNA) is a unique form of circular DNA that exists outside of normal chromosomes. Found exclusively in tumor cells, it often carries cancer-promoting genes (oncogenes) and is ...
The DNA-repair mechanism referred to as non-homologous end-joining (NHEJ) involves the Ku proteins (Ku70 and Ku80), DNA ligase IV and Lif1/XRCC4. Meiotic cells down-regulate NHEJ, to favour homologous ...
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Repairing broken DNA and saving our cells
The DNA in our cells is constantly damaged, with the most severe being the simultaneous breakage of both strands that compose it. In a study published in Nature Communications, scientists reveal in ...
Extrachromosomal DNA (ecDNA) is a unique form of circular DNA that exists outside of normal chromosomes. Found exclusively in tumor cells, it often carries cancer-promoting genes (oncogenes) and is ...
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