NFL Week 2 expert picks, score predictions

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Week 2 NFL odds, picks, predictions: Computer model backs Seahawks and Buccaneers
SportsLine's advanced model has simulated every game in the Week 2 NFL schedule 10,000 times and locked in its NFL best bets today

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NFL week 2 predictions straight up, NFL picks against the spread
SportsLine · 11h
NFL odds, lines, spreads: 2026 Week 2 picks, predictions from proven model: 5-way parlay pays over 22-1
'Thursday Night Football' prediction, odds, spread, time: Lions vs. Bills picks from expert on 22-11 roll
Playoff contenders look to stay perfect on the season when the Detroit Lions battle the Buffalo Bills in a key interconference Week 2 matchup on 'Thursday Night Football' as Buffalo officially opens u...

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Lions vs. Bills 'Thursday Night Football' betting odds, picks and predictions: Best bets, player props
49ers vs Dolphins predictions, picks, odds for NFL Week 2 game Sunday
NFL Week 2: Bills vs. Lions picks, props, anytime TD scorers for high-scoring Thursday Night Football matchup
Buffalo is set to open its new home stadium on Thursday night, and the expectations are high for points: Vegas has this game lined at a whopping 54.5, and it's juiced to the Over to boot.

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Week 2 NFL preview: Chicago Bears vs. Minnesota Vikings
Syracuse vs. Pittsburgh odds, picks, predictions: Betting preview, start time for Week 3 college football

NFL Week 2 TV schedule: Full list of games for 2026-27 season

The 2026-27 NFL season kicks off on Thursday, September 17, setting the tone for another busy weekend across the league.

Lions vs. Bills betting odds, prediction, best bet

Here's the latest betting odds for the Detroit Lions at the Buffalo Bills. Plus, our best bet and a prediction.