Our cells accumulate DNA mistakes as we age, eating less slowed that process in mice Every cell carries a molecular record of time. As DNA is copied, repaired and exposed to damage, mutations ...
As the human brain takes shape before birth, a remarkable type of stem cell helps give it many of the features that make it ...
Metabolic pathway presents promising new target for treating rare, aggressive childhood cancer by Jennifer Brown, University of Iowa edited by Sadie Harley, reviewed by Robert Egan Editors' notes The ...
Pancreatic ductal adenocarcinoma is the most common type of pancreatic cancer and has a low five-year survival rate. It begins with a reversible state called acinar-to-ductal metaplasia, where cells ...
Missense mutations influence protein abundance in prostate cancer. Using a SILAC-based quantitative proteomics approach, we identified significant proteomic differences between healthy and tumor ...
Mutations in the lipid transporter ABCA7 are known to elevate the risk of Alzheimer’s disease, but how they do so has been murky. Now, scientists led by Li-Huei Tsai at MIT in Cambridge, Massachusetts ...
Despite the significance of immune checkpoint inhibitors (ICIs) in solid tumor treatment, identifying ICI-sensitive populations remains a challenge. Mutations in DNA damage response (DDR) pathway ...
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