Nature

Morphological Quantification of Emphysema in Small Human Lung Specimens: Comparison of Methods and Relation with Clinical Data

Lung specimens were obtained from patients undergoing lobectomy or pneumonectomy for a localized malignant pulmonary process, at the University Lung Center Nijmegen, or Rijnstate Hospital Arnhem, the ...
The New England Journal of Medicine

Small-Airway Obstruction and Emphysema in Chronic Obstructive Pulmonary Disease

The major sites of obstruction in chronic obstructive pulmonary disease (COPD) are small airways (<2 mm in diameter). We wanted to determine whether there was a relationship between small-airway ...
Nature

Therapeutic effects of adipose-derived stem cells pretreated with pioglitazone in an emphysema mouse model

There is no therapy currently available that influences the natural history of disease progression in patients with chronic obstructive pulmonary disease (COPD). Although stem cell therapy is ...
Nature

Chemokine receptor CXCR3 is important for lung tissue damage and airway remodeling induced by short-term exposure to cigarette smoking in mice

CXCR3 knockout (CXCR3-/-) mice were used. Differences in airspace enlargement, mRNA expression of matrix metalloproteinases (MMPs), transforming growth factor (TGF) β1, CXCL10 in lung homogenates, and ...
Nature

Intratracheal transplantation of mesenchymal stem cells simultaneously attenuates both lung and brain injuries in hyperoxic newborn rats

Bronchopulmonary dysplasia is an independent risk factor for adverse neurodevelopmental outcomes in premature infants. We investigated whether attenuation of hyperoxic lung injury with intratracheal ...