In a new study, researchers from Johns Hopkins Medicine say they have uncovered insights as to why lupus symptoms and severity present differently in individuals with the autoimmune condition, which ...

Innate immune sensors—known as pattern recognition receptors (PRRs)—detect specific molecular components of bacterial or ...

Type 1 interferons (IFNs) play a central role in the development and disease course of systemic lupus erythematosus (SLE). In a new study, researchers explored SLE disease activity and type I ...

Regarding long-term outcome, a meta-analysis of 12 studies involving 765 interferon-treated patients followed up for a mean period of 6.1 years showed that decompensation, development of ...

A team led by researchers at the University of Cologne has identified a protein called ANKIB1 that acts as a volume dial for the body’s frontline immune defenses, controlling how strongly cells ...

When pathogens attack the body, the innate immune system goes to work protecting against the invading disease. The innate immune system is the first line of defense. It detects precisely what the ...

Increasing Incidence of Late Second Malignancies After Conditioning With Cyclophosphamide and Total-Body Irradiation and Autologous Bone Marrow Transplantation for Non-Hodgkin’s Lymphoma Ten phase III ...

The advantages of the interferons include their efficacy compared with antivirals, the absence of viral resistance, the durability of response, and their ability to cause loss of HBsAg -- all of which ...