Mast cell leukemia (MCL) is a quick-progressing condition that leads to the buildup of mast cells in your bone marrow and other tissues. It falls into a group of diseases collectively known as ...

Mast cell leukemia (MCL) is a rare type of blood cell cancer. It causes the body to produce a large number of mast cells that can affect different areas of the body. MCL is a subtype of mastocytosis.

Mast cells are a type of innate immune cell. They contain large granules that are packed with immunomodulatory and vasoactive molecules, which are released following mast cell degranulation. Mast ...

Mast cell activation syndrome, or disease (MCAS), is a condition that causes mast cells to release these substances too frequently, resulting in severe allergic reactions. After detecting an allergen, ...

Mast cells develop from hematopoietic progenitors in response to stem-cell factor (KIT ligand), which is the ligand of the CD117 transmembrane tyrosine kinase receptor, encoded by KIT. CD117 regulates ...