Preclinical model systems are invaluable tools for drug discovery and development. But many complex diseases, such as nonalcoholic steatohepatitis (NASH), are difficult to recapitulate in the ...

Although modern oncology trial design has promoted adaptive designs as a new aspect of clinical trials, we note that adaptive elements have played a long-standing role in oncology clinical trials, ...

The de novo design of amino acid sequences to fold into desired structures is a way to reach a more thorough understanding of how amino acid sequences encode protein structures and to supply methods ...