News Medical

Investigating the role of cyclins and cyclin-dependent kinases in host restriction of SARS-CoV-2 infection

In a recent study posted to the bioRxiv* pre-print server, researchers investigated coronavirus disease 2019 (COVID-19)-triggered changes in the levels of cyclins and cyclin-dependent kinases (CDKs) ...
Nature

The classical and minimal models of cell cycle control

Where and when do cyclins act on the cell cycle? (A) Cycling cells undergo three major transitions during their cell cycle. The beginning of S phase is marked by the onset of DNA replication, the ...
Nature

The path to destruction for D-type cyclin proteins

Charupong Saengboonmee is in the Department of Cancer Biology, Dana-Farber Cancer Institute, and in the Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts 02215 ...
JSTOR Daily

A negative reciprocal regulatory axis between cyclin D1 and HNF4α modulates cell cycle progression and metabolism in the liver

Hepatocyte nuclear factor 4α (HNF4α) is a master regulator of liver function and a tumor suppressor in hepatocellular carcinoma (HCC). In this study, we explore the reciprocal negative regulation of ...
EurekAlert!

Aging | The deubiquitylase USP7 is a novel cyclin F-interacting protein and regulates cyclin F protein stability

“This study highlights a potential role for the cyclin F-USP7 axis in pathological conditions, including cancer and neurodegenerative diseases.” Orderly progression through the cell cycle is driven by ...