Taking out the garbage is a crucial step in housecleaning. Similarly, autophagy is the body’s first-line of defense against the buildup up of toxic substances, degrading old organelles and proteins to ...

Nerve cells regulate and routinely refresh the collection of calcium channels that enable them to send messages across circuit connections. The nervous system works because neurons communicate across ...

The regulation of calcium is in turn fundamentally important for excitatory transmission in the central nervous system: When neurons communicate with each other, calcium channels open at synapses ...

Neurobiologists have found new evidence that specific calcium channel subunits play a crucial role in the development of excitatory and inhibitory synapses. The ability of the human brain to process ...

DALLAS – July 17, 2003 – Abnormally high calcium levels spurred on by a mutated gene may lead to the death of neurons associated with Huntington's disease, an inherited genetic disorder, characterized ...

Praxis Precision Medicines' ulixacaltamide (PRAX-944) is a potent and selective small molecule T-type Ca2+ channel blocker being developed for the potential treatment of essential tremor. ET is a ...

(1) A nerve impulse arrives. (2) This causes calcium ion channels to open, resulting in an influx of calcium ions in the terminal. (3) This causes synaptic vesicles to fuse with the terminal membrane, ...

Researchers at MIT have developed a calcium indicator, or sensor, that can overcome one of the main problems associated with a technique that is used to visualize, or map the activity of individual ...

It is vital to the regulation of cell activities through its role as a second messenger. Calcium signaling is the process whereby low cytoplasmic concentrations are deliberately increased to activate ...