In our laboratory, we have used HR-CGH as a screening method for cryptic chromosomal imbalances for several years. In an initial study, we found a cryptic chromosomal imbalance in 5 out of 50 patients ...

Array CGH has been implemented using a wide variety of techniques. The initial approaches used arrays with elements produced by spotting DNA obtained directly from large-insert genomic clones such as ...

Comparative genomic hybridization (CGH) was developed to identify pathogenic DNA copy-number changes (e.g., duplications, deletions) on a genome-wide scale, and to map these changes to genomic ...

Comparative genomic hybridization (CHG) provides the densest coverage of probes for CNV detection, but the traditional technique using bacterial artificial chromosome arrays is time consuming and not ...

Acacia Research Corporation has announced that its CombiMatrix group’s subsidiary Combimatrix Molecular Diagnostics (CMDX) and Array Genomics Inc. will co-develop, market, and sell an exciting series ...

Agilent Technologies Inc. has announced that scientists using an Agilent custom-designed comparative genomic hybridization (CGH) array have sequenced the entire gene map of a Korean male. An ...

Expert Rev Mol Diagn. 2012;12(3):253-264. Starczynowski et al. (2008) Low-risk MDS (44; IPSS ≤1.0) Discovery: array CGH with whole-genome BAC tiling array Validation: FISH of a selected locus Paired ...

SANTA CLARA, Calif.--(BUSINESS WIRE)--Agilent Technologies Inc. (NYSE:A) today announced that scientists using the company’s comparative genomic hybridization (CGH) technology have shown that cancer ...

Early efforts to examine genomic changes in the clinical setting relied on cytogenetic techniques such as chromosome karyotyping, a widely used approach to examine chromosomes and identify changes ...

BRAF V600E mutations in benign and malignant peripheral nerve sheath tumors. Background: Gain or loss of chromosome arms are frequently detected in gastrointestinal stromal tumors (GISTs), and have ...

Expert Rev Mol Diagn. 2012;12(3):253-264. Cytogenetics can detect clonal CNAs not identified using arrays when they occur in less than 20–30% of metaphases; Arrays cannot detect copy neutral balanced ...