T cell development is a tightly regulated process that transforms immature thymocytes into mature T cells with distinct functionalities. In the thymus, precursor cells undergo a series of selection ...

Researchers from the School of Veterinary Medicine and Perelman School of Medicine have found that YY1 knockout pro-B cells can generate T lineage cells helping B cells produce antibodies. Development ...

The Notch signaling pathway plays a pivotal role in determining cell fate, especially in the development and function of T cells. But mimicking this highly mechanical, contact-dependent pathway in the ...

In their new study, the LJI scientists are the first to show that GPR25 is induced by a signaling molecule called TGF-β.

Progress in the treatment of T-cell blood cancers – which are rare – has also been modest. So, much remains to be done to ...

T-cell therapy represents a groundbreaking advancement in cancer treatment, particularly for hematological malignancies. Despite its potential to offer curative outcomes, the field faces significant ...

A new type of cancer cell that "warrants urgent investigation" has been discovered in childhood leukemia and could impact clinical care. Research into new or repurposed treatments that target this new ...