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Arizona Cardinals vs San Francisco 49ers NFL game

Arizona Cardinals vs. San Francisco 49ers NFL game: How to watch, kickoff time, TV channel and more

The Sunday afternoon Cardinals vs. 49ers game will kick off at 4:25 p.m. ET on FOX. (Out-of-market fans can catch the game on YouTube TV 's Sunday Ticket, or NFL+.) Here's everything you need to know about how to watch this Sunday's game between the Cardinals and the 49ers, and the full Week 3 schedule for the rest of the league.

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How to watch San Francisco 49ers vs. Arizona Cardinals: TV channel, streaming info

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Where to watch 49ers vs. Cardinals free livestream today (9/21/25) without Streameast

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How to watch Jacksonville Jaguars vs. Houston Texans: TV channel, streaming info

The Jacksonville Jaguars (1-1) host an AFC South battle against the Houston Texans (0-2) on Sunday, September 21, 2025 at EverBank Stadium.

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No Moral Victories in Losing, Says Coach McDaniel After Dolphins Drop to 0-3 in 31-21 Loss to Bills

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Our predictions for the Green Bay Packers Week 3 game against the Cleveland Browns

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Miami football vs Florida highlights: No. 6 Hurricanes pull away, set up showdown with FSU

The Hurricanes will wear their traditional orange home jerseys with white helmets and pants.

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How to buy Baltimore Ravens vs. Detroit Lions tickets

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NFL Week 3 predictions, picks: Predicting winners, scores for games on NFL Week 3 schedule

49ers to start Jones at QB

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Kurtenbach: Can Mac Jones keep it up? Three predictions for 49ers-Cardinals

To be 3-0 is a boon for a team’s playoff chances — it’s hay in the barn.

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49ers expect to start Mac Jones again with Brock Purdy questionable

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49ers' Mac Jones: Primed for another start

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49ers' Brock Purdy 'Highly Unlikely' to Start vs. Cardinals with Multiple Injuries

San Francisco 49ers quarterback Brock Purdy is "highly unlikely" to start but could still play in Sunday's Week 3 matchup against the Arizona Cardinals, head coach Kyle Shanahan told reporters Friday.

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Brock Purdy injury: Where Mac Jones ranks among NFL backup QBs most likely to deliver wins in Week 3

· 10h

49ers' decision to keep Brock Purdy out another week may end up being the best thing to ever happen to Mac Jones

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49ers vs. Cardinals 2025 Week 3: Injured players, inactives, latest injury updates

Wanting information about injured players on the 49ers and Cardinals? We've got your back.

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49ers’ Brock Purdy Gives Major Injury Update on Himself

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Eagles vs. Rams 2025 Week 3: Injured players, inactives, latest injury updates

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Cardinals vs. 49ers: Where to watch NFL Week 3, betting odds, picks, promos for Kyler Murray vs. Mac Jones

San Francisco is a 2.5-point favorite in the latest Cardinals vs. 49ers odds from SportsLine consensus, while the over/under for total points scored is 44.5. The 49ers are -150 money line favorites (risk $150 to win $100),

49ers vs. Cardinals 2025 Prediction, Odds, Picks - Sep 21

Preview the Week 3 matchup between the San Francisco 49ers and Arizona Cardinals with predictions, odds, over/under, spread, betting lines and more.

49ers’ 5 keys to winning home opener against Arizona Cardinals

Mac Jones is expected to again start in place of Brock Purdy as the 49ers host the Arizona Cardinals on Sunday.

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Cardinals' Final Moves vs 49ers Reveals Cause for Concern

The Arizona Cardinals made their two standard practice squad elevations ahead of Week 3's road test against the San Francisco 49ers, and there might

USA TODAY Touchdown Wire on MSN

Jauan Jennings injury update: Will 49ers WR play vs. Cardinals?

San Francisco 49ers wide receiver Jauan Jennings is questionable to suit up in Week 3 vs. the Arizona Cardinals. Here's the latest on his injuries.

Niners Wire on MSN

Fantasy Football start/sit recommendations for the 49ers in Week 3 vs. Cardinals

The San Francisco 49ers and Arizona Cardinals will meet on Sunday. Here's what fantasy owners should do with their 49ers in Week 3.

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The 49ers' Keys to Beating the Cardinals and Quarterback Kyler Murray

Arizona comes into this game 2-0, but as a more flawed team than the one that swept San Francisco last year. The Cardinals' running game has not gotten untracke

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49ers place Spencer Burford on IR, elevate QB Adrian Martinez to face Cardinals

Matt Maiocco details the 49ers' latest roster moves ahead of San Francisco's Week 3 matchup with the Arizona Cardinals on Sunday at Levi's Stadium.