Brock Purdy, san francisco 49ers and Cardinals
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49ers to start Jones at QB
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Injury updates, predictions from 49ers Week 3 opponent
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Mac Jones is expected to again start in place of Brock Purdy as the 49ers host the Arizona Cardinals on Sunday.
Arizona Cardinals QB Kyler Murray is always a handful for defensive coordinators thanks to his natural arm talent and elite athleticism to extend plays and gain serious yardage with his legs. The San Francisco 49ers know that best, especially after being swept by the Cardinals in 2024.
Murray shined last season against the 49ers, starting on his second snap when he raced 50 yards for a touchdown and not slowing down. Murray capped that game at Levi’s Stadium by throwing a TD pass in the fourth quarter and leading a game-winning field-goal drive as the Cardinals erased a 10-point deficit.
The Arizona Cardinals dominated on the ground in 2024, finishing second in yards per carry. 2025 has been more of a struggle for their rushing attack.
The Arizona Cardinals and San Francisco 49ers both hope to emerge to 3-0 to begin the 2025 season, though the NFC West rivals stand in each other's way of doing just that on Sunday. Arizona is 2-0 for the first time since 2021 while the Niners have now done so in the last three-of-five seasons.
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49ers places 4th-year guard on IR
The San Francisco 49ers, ahead of their Week 3 home opener against the Arizona Cardinals, announced multiple roster moves, chief among them was placing fourth-year offensive lineman Spencer Burford on injured reserve with a knee injury, ESPN's Adam Schefter reported.
USA Today's NFL experts make their picks for a Week 3 showdown between the San Francisco 49ers and Arizona Cardinals
The Arizona Cardinals are the away team in Week 3's tilt against the San Francisco 49ers, though the organization will be wearing their all-red looks