The San Francisco 49ers face the Arizona Cardinals on Sunday, Sept. 21, 2025 in Week 3 of the NFL season at State Farm Stadium in Glendale, Arizona.

Mac Jones is expected to again start in place of Brock Purdy as the 49ers host the Arizona Cardinals on Sunday.

Happy gameday one and all. The Arizona Cardinals are taking on their division rival San Francisco 49ers this afternoon and it is going to be a big one. The Niners are hurting, the Cardinals are hurting and it is only week three,

The Arizona Cardinals have a chance at a 3-0 start when they head to San Francisco to take on the 49ers. It's their toughest matchup yet this year.

www.si.com/nfl/49ers Why these injuries could swing the 49ers' Week 2 matchup vs. Arizona East Grays Harbor Fire and Rescue says it had put out a car fire that was close to a building in the Murray Place neighborhood. Fire crews arrived on the scene of the fire at about 8:20 p.m.

The San Francisco 49ers are looking to rebound after an uneven 2024 season that saw the team finish 6-11 amidst a litany of injuries to key skill positions.

The Arizona Cardinals dominated on the ground in 2024, finishing second in yards per carry. 2025 has been more of a struggle for their rushing attack.

San Francisco is a 2.5-point favorite in the latest Cardinals vs. 49ers odds from SportsLine consensus, while the over/under for total points scored is 44.5. The 49ers are -150 money line favorites (risk $150 to win $100),